Retinoblastoma Abstract: Retinoblastoma is the most frequent malignant tumour in children with an incidence of 1 in 15, live births.
Sixty per cent of retinoblastoma cases involve one eye unilateral: Forty percent of retinoblastoma cases are bilateral: All bilateral and multifocal unilateral forms are hereditary. Hereditary retinoblastoma is a cancer predisposition syndrome: They also have an increased risk of developing other types of cancer. Leucocoria and strabismus are the most frequent revealing symptoms.
Diagnosis is made by fundoscopy. Treatment of patients with doz rencontre should take into account the various aspects of the disease: Enucleation is still often necessary in unilateral disease; adjuvant treatment might be given according to histological risk factors.
doz rencontre Conservative treatmentmay be to at least one doz rencontre in most of bilateral cases: External beam radiation therapy should be restricted to large ocular tumours and diffuse vitreous seeding ocular because of the risk of late effects, including secondary sarcoma. Long term follow-up of patients with retinoblastoma is important, as well as information given at an early stage to them and their family about the doz rencontre of second primary tumours and of transmission to their off springs.
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